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Keywords:

  • biomaterials;
  • cell screening;
  • cell proliferation;
  • combinatorial methods;
  • polymer scaffolds;
  • screening;
  • tyrosine-derived polycarbonates
Thumbnail image of graphical abstract

A combinatorial method for screening cell–biomaterial interactions in 3D is presented; polymeric, salt-leached scaffolds with varied composition and properties are present in a 96-well plate. Previous high-throughput approaches for screening cell–material interactions have focused on planar 2D surfaces or films. However, biomaterials are commonly used in a 3D scaffold format and cells behave more physiologically when cultured in 3D.