Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds


  • We gratefully acknowledge Prof. C. Russ Middaugh and Prof. Stevin Gehrke for the use of equipment and the Microscopy Laboratory for assistance with imaging. We are grateful for support from funding agencies such as the Juvenile Diabetes Research Foundation, the American Heart Association, the Cystic Fibrosis Foundation and the NIH (1R03 AR054035-01A1, P20 RR016443 and P20 RR015563 (C.B.) and 1R21DE017673-01A1 (M.S.D.). Supporting Information is available online from Wiley InterScience or from the authors.


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Colloidal gels are fabricated using oppositely charged, biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles that interact to form stable 3D structures. Malleability under shear and strong static cohesion facilitate the fabrication of shape- specific tissue-engineering scaffolds.