Dynamic Imaging of Functionalized Multi-Walled Carbon Nanotube Systemic Circulation and Urinary Excretion


  • This work was supported by The School of Pharmacy, University of London and the United Kingdom Department and Trade & Industry (DTI) ‘UK-Texas Collaborative Initiative' programme (grant QCBB/013/00057), the CNRS and the Agence Nationale de la Recherche (grant ANR-05-JCJC-0031-01), the University of Trieste and Italian MUR (PRIN 2006, prot.2006034372). L. L. acknowledges support by the Portuguese Foundation for Science and Technology (FCT/MCES) for the award of a PhD fellowship (Ref.: SFRH/BD/21845/2005). G. P. is grateful to French Ministry for Research and New Technologies for a post-doctoral fellowship (GenHomme Network 2003). This work was also supported by the European Union, NEURONANO program (NMP4-CT-2006-031847). TEM images were collected at the Microscopy Facility Platform of Esplanade Campus (IBMP, Strasbourg, France). The authors would also like to thank J. Sumner, UTHSCSA Radiology Department, for preparation of the figures of gamma camera images. Supporting Information is available online from Wiley InterScience or from the authors.


original image

Intravenously administered multi-walled carbon nanotubes, functionalized with DTPA and radiolabeled with Indium-111, were dynamically tracked in vivo using a microSingle Photon Emission Tomography scanner. Imaging showed that nanotubes enter the systemic blood circulation and within 5 min begin to permeate through the renal glomerular filtration system into the bladder.