Biodegradable Xylitol-Based Polymers

Authors

  • Joost P. Bruggeman,

    1. Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
    2. Department of Plastic and Reconstructive Surgery Erasmus Medical Center, Erasmus University Rotterdam 3015 CE Rotterdam (The Netherlands)
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  • Christopher J. Bettinger,

    1. Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
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  • Christiaan L.E. Nijst,

    1. Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
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  • Daniel S. Kohane,

    1. Department of Anaesthesiology, Children's Hospital Harvard Medical School Boston, MA 02114 (USA)
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  • Robert Langer

    Corresponding author
    1. Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
    • Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA).
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  • J.P.B. acknowledges financial support from the J.F.S. Esser Stichting and the Stichting Prof. Michaël-Van Vloten Fonds. CJB was funded by a Charles Stark Draper Laboratory Fellowship. C.L.E.N. acknowledges the financial support of Shell and KIVI. This work was funded by NIH grant HL060435 and through a gift from Richard and Gail Siegal.

Abstract

original image

Synthetic polymers composed of metabolites endogenous to the mammalian organism are designed. The design is based on the monomer xylitol, which possesses a wide range of physical properties that are biologically relevant. Xylitol-based hydrogels and elastomers are biocompatible in vitro and in vivo, compared to the prevalent synthetic polymer poly(L-lactic-co- glycolic acid) (PLGA). It furthermore provides a platform to tune mechanical properties, degradation profiles, and cell attachment.

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