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Sequence-Dependent Fluorescence of DNA-Hosted Silver Nanoclusters


  • Supported by a UCSB Academic seed grant (E.G.) and by NSF-CCF-622257 (D.B. and D.K.F.). P.O'N. acknowledges support as a GK-12 Fellow (NSF-DGE-0440576). Supporting Information is available online from Wiley InterScience or from the authors.


DNA-bound silver nanoemitters reside in single-stranded regions of the host DNA. Their fluorescence is sensitive to both the DNA base sequence and its secondary structure. Fluorescence from individual emitters hosted by DNA “hairpins”, which are suitable for incorporation into DNA scaffolds, is detectable using standard epifluorescence techniques.

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