Communication

Human Embryoid Bodies Containing Nano- and Microparticulate Delivery Vehicles†

  1. Lino Ferreira1,2,3,
  2. Trevor Squier1,
  3. Hyoungshin Park1,
  4. Hannah Choe1,
  5. Daniel S. Kohane1,4,
  6. Robert Langer1,*

Article first published online: 16 MAY 2008

DOI: 10.1002/adma.200702404

Issue

Advanced Materials

Advanced Materials

Volume 20, Issue 12, pages 2285–2291, June 18, 2008

Additional Information

How to Cite

Ferreira, L., Squier, T., Park, H., Choe, H., Kohane, D. S. and Langer, R. (2008), Human Embryoid Bodies Containing Nano- and Microparticulate Delivery Vehicles. Advanced Materials, 20: 2285–2291. doi: 10.1002/adma.200702404

Author Information

  1. 1

    Department of Chemical Engineering, Massachusetts Institute of Technology, E25-342 MIT, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)

  2. 2

    Center of Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra (Portugal)

  3. 3

    Biocant – Biotechnology Innovation Center, 3060-197 Cantanhede (Portugal)

  4. 4

    Laboratory for Biomaterials and Drug Delivery, Department of Anesthesia, Division of Critical Care Medicine, Children's Hospital Boston, 300 Longwood Ave., Boston, MA 02115 (USA)

*Department of Chemical Engineering, Massachusetts Institute of Technology, E25-342 MIT, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA).

  1. †

    The authors would like to thank Jason Fuller and Jon Aanestad for valuable suggestions and the financial support of Fundação para a Ciência e a Tecnologia (SFRH/BPD/14502/2003; fellowship to L.F), NIH (grants HL060435, DE13023 and HL076485) and the MIT–Portugal Program (focus in Bioengineering). Supporting Information is available online from Wiley InterScience or from the authors.

Publication History

  1. Issue published online: 18 JUN 2008
  2. Article first published online: 16 MAY 2008
  3. Manuscript Revised: 27 DEC 2007
  4. Manuscript Received: 22 SEP 2007

Funded by

  • Fundação para a Ciência e a Tecnologia. Grant Number: SFRH/BPD/14502/2003

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Keywords:

  • bionanotechnology;
  • intracellular trafficking;
  • microparticles;
  • nanoparticles;
  • stem cells

Graphical Abstract

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Differentiation of human embryonic stem cells is affected by the incorporation of growth-factor-releasing particles in embryoid bodies. Incorporation of these particles has a minimal effect on cell viability and proliferation but a large impact on differentiation. The figure shows the distribution of TRITC-labeled microparticles in embryoid bodies, as evaluated by confocal microscopy.

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