Get access

Integrated Catalytic Activity of Patterned Multilayer Films Based on pH-Induced Electrostatic Properties of Enzymes


  • This work was supported by the ERC Program of MOST/KOSEF (R11-2005-048-00 000-0), research program 2007 of Kookmin University, Seoul R&BD Program (NT070 091) (for Prof. Jinhan Cho), NRL (R0A-2007-000-20 105-0) program (for Prof. Hyunjung Shin), and the Australian Research Council (for Prof. Frank Caruso). Supporting Information is available online from Wiley InterScience or from the author.


original image

Patterned multilayer structures are fabricated on enzymatic surfaces using pH-induced variations in the electrostatic properties of these surfaces, as schematically illustrated in the figure. Notably, this process does not require photolithography or the use of hydrophobic components that could lead to a loss of enzymatic activity. Highly effective electrochemical sensors incorporating metal nanoparticles and biocatalysts are fabricated using this approach.

Get access to the full text of this article