Advanced Materials

Multiplex Imaging of Pancreatic Cancer Cells by Using Functionalized Quantum Rods

Authors

  • Ken-Tye Yong,

    1. Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York Buffalo, NY 14260-4200 (USA)
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  • Indrajit Roy,

    1. Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York Buffalo, NY 14260-4200 (USA)
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  • Haridas E. Pudavar,

    1. Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York Buffalo, NY 14260-4200 (USA)
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  • Earl J. Bergey,

    1. Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York Buffalo, NY 14260-4200 (USA)
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  • Kenneth M. Tramposch,

    1. Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York Buffalo, NY 14260-4200 (USA)
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  • Mark T. Swihart,

    1. Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260-4200 (USA)
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  • Paras N. Prasad

    Corresponding author
    1. Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York Buffalo, NY 14260-4200 (USA)
    • Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York Buffalo, NY 14260-4200 (USA).
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  • This study was supported by grants from the NCI RO1CA119397, the John R. Oishei Foundation, the Chemistry and Life Sciences Division of the Air Force Office of Scientific Research, and the University at Buffalo Interdisciplinary Research and Creative Activities Fund. Support from the Center of Excellence in Bioinformatics and Life Sciences at the University at Buffalo is also acknowledged. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

A technique for labeling of live human cancer cells is presented. The imaging technique employs semiconductor quantum rods of CdSe/CdS/ZnS for multiplex labeling. The technique is further used to diagnose human pancreatic cancer by conjugating QRs with monoclonal antibodies (anti-Claudin 4 and anti-mesothelin).

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