D.E.R. and A.M. are joint first authors.
Surface Gradient of Functional Heparin†
Article first published online: 29 FEB 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 20, Issue 6, pages 1166–1169, March 18, 2008
How to Cite
Robinson, D. E., Marson, A., Short, R. D., Buttle, D. J., Day, A. J., Parry, K. L., Wiles, M., Highfield, P., Mistry, A. and Whittle, J. D. (2008), Surface Gradient of Functional Heparin. Adv. Mater., 20: 1166–1169. doi: 10.1002/adma.200702586
- Issue published online: 19 MAR 2008
- Article first published online: 29 FEB 2008
- Manuscript Revised: 28 NOV 2007
- Manuscript Received: 15 OCT 2007
- Biocompatible materials;
- Heparin gradients;
- Protein immobilization;
- Plasma polymerization;
A gradient of functional heparin is fabricated onto a surface chemical gradient of plasma-polymerized allyl amine (see figure). While heparin functionality changes across the gradient, increased adsorption of heparin onto the surface is not accompanied with a continued, corresponding rise in heparin function.