Communication

Monodisperse Chitosan Microspheres with Interesting Structures for Protein Drug Delivery†

  1. Wei Wei1,2,
  2. Lan Yuan3,
  3. Gang Hu4,
  4. Lian-Yan Wang1,
  5. Jie Wu1,
  6. Xue Hu1,
  7. Zhi-Guo Su1,
  8. Guang-Hui Ma1,*

Article first published online: 15 MAY 2008

DOI: 10.1002/adma.200702663

Issue

Advanced Materials

Advanced Materials

Volume 20, Issue 12, pages 2292–2296, June 18, 2008

Additional Information

How to Cite

Wei, W., Yuan, L., Hu, G., Wang, L.-Y., Wu, J., Hu, X., Su, Z.-G. and Ma, G.-H. (2008), Monodisperse Chitosan Microspheres with Interesting Structures for Protein Drug Delivery. Advanced Materials, 20: 2292–2296. doi: 10.1002/adma.200702663

Author Information

  1. 1

    National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100080 Beijing (P.R. China)

  2. 2

    Graduate University of Chinese Academy of Sciences, 100049 Beijing (P.R. China)

  3. 3

    Medical and Healthy Analytical Center, Peking University Health Science Center, 100083 Beijing (P.R. China)

  4. 4

    Unilever Research China, 200233 Shanghai (P.R. China)

*National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100080 Beijing (P.R. China).

  1. †

    This work was supported by the National Nature Science Foundation of China (20 536 050, 50 703 043), Chinese Academy of Sciences (KJCX2-YW-M02), and the Knowledge Innovation Program. Supporting Information is available online from Wiley InterScience or from the author.

Publication History

  1. Issue published online: 18 JUN 2008
  2. Article first published online: 15 MAY 2008
  3. Manuscript Revised: 18 JAN 2008
  4. Manuscript Received: 24 OCT 2007

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Keywords:

  • crosslinking;
  • drug delivery;
  • microspheres;
  • proteins

Graphical Abstract

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Monodisperse chitosan microspheres with different structures are prepared and loaded with proteins, as exemplified in the figure. The different types of microspheres show different protein release profiles, which implies that that their properties can be adjusted to fit the needs of different therapeutic applications. The structural properties of the microspheres are varied by adjusting the surface charge, cavity size, and wall porosity.

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