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Advanced Materials

Monodisperse Chitosan Microspheres with Interesting Structures for Protein Drug Delivery

Authors

  • Wei Wei,

    1. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100080 Beijing (P.R. China)
    2. Graduate University of Chinese Academy of Sciences, 100049 Beijing (P.R. China)
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  • Lan Yuan,

    1. Medical and Healthy Analytical Center, Peking University Health Science Center, 100083 Beijing (P.R. China)
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  • Gang Hu,

    1. Unilever Research China, 200233 Shanghai (P.R. China)
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  • Lian-Yan Wang,

    1. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100080 Beijing (P.R. China)
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  • Jie Wu,

    1. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100080 Beijing (P.R. China)
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  • Xue Hu,

    1. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100080 Beijing (P.R. China)
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  • Zhi-Guo Su,

    1. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100080 Beijing (P.R. China)
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  • Guang-Hui Ma

    Corresponding author
    1. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100080 Beijing (P.R. China)
    • National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100080 Beijing (P.R. China).
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  • This work was supported by the National Nature Science Foundation of China (20 536 050, 50 703 043), Chinese Academy of Sciences (KJCX2-YW-M02), and the Knowledge Innovation Program. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

Monodisperse chitosan microspheres with different structures are prepared and loaded with proteins, as exemplified in the figure. The different types of microspheres show different protein release profiles, which implies that that their properties can be adjusted to fit the needs of different therapeutic applications. The structural properties of the microspheres are varied by adjusting the surface charge, cavity size, and wall porosity.

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