Sensitivity Enhancement of Surface-Plasmon Resonance Imaging by Nanoarrayed Organothiols

Authors

  • Patrícia Lisboa,

    1. European Commission, Institute of Health and Consumer Protection, NMI TP203, Via E. Fermi 2749, 21021 Ispra (VA) (Italy)
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  • Andrea Valsesia,

    1. European Commission, Institute of Health and Consumer Protection, NMI TP203, Via E. Fermi 2749, 21021 Ispra (VA) (Italy)
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  • Ilaria Mannelli,

    1. European Commission, Institute of Health and Consumer Protection, NMI TP203, Via E. Fermi 2749, 21021 Ispra (VA) (Italy)
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  • Stephane Mornet,

    1. European Commission, Institute of Health and Consumer Protection, NMI TP203, Via E. Fermi 2749, 21021 Ispra (VA) (Italy)
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  • Pascal Colpo,

    Corresponding author
    1. European Commission, Institute of Health and Consumer Protection, NMI TP203, Via E. Fermi 2749, 21021 Ispra (VA) (Italy)
    • European Commission, Institute of Health and Consumer Protection, NMI TP203, Via E. Fermi 2749, 21021 Ispra (VA) (Italy).
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  • François Rossi

    1. European Commission, Institute of Health and Consumer Protection, NMI TP203, Via E. Fermi 2749, 21021 Ispra (VA) (Italy)
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  • We thank Simone Malfara and Giovanni Maselli for technical support.

Abstract

original image

Crystalline organothiol nanoarrays improve the detection sensitivity of surface-plasmon resonance (SPR) by a factor of five in comparison to noncrystalline nanopatterns and uniformly carboxylic surfaces. SPR images taken during the detection of an immunoreaction show a brighter color in the nanoarray area of the surface, which is the result of higher detection sensitivity. Sensor surfaces with nanoarrays may therefore provide future applications for the immobilization of biomolecules on biosensing surfaces.

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