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Keywords:

  • dendrimers;
  • functionalization;
  • iron oxide;
  • magnetic resonance imaging;
  • metal nanoparticles
Thumbnail image of graphical abstract

A powerful magnetic nanoprobe with folic acid (FA)-targeting ligands is fabricated by dendrimer functionalization of Fe3O4 nanoparticles (NPs) precoated with crosslinkable and biocompatible polymer multilayer shells. This magnetic probe allows for magnetic resonance imaging of FA receptor-overexpressing tumor cells in vitro and of an early-stage tumor model in vivo (see picture).