Communication

Dendrimer-Functionalized Shell-crosslinked Iron Oxide Nanoparticles for In-Vivo Magnetic Resonance Imaging of Tumors†

  1. Xiangyang Shi1,*,
  2. Su He Wang1,*,
  3. Scott D. Swanson2,
  4. Song Ge3,
  5. Zhengyi Cao1,
  6. Mary E. Van Antwerp1,
  7. Kevin J. Landmark3,
  8. James R. Baker Jr1,*

Article first published online: 11 APR 2008

DOI: 10.1002/adma.200702770

Issue

Advanced Materials

Advanced Materials

Volume 20, Issue 9, pages 1671–1678, May 5, 2008

Additional Information

How to Cite

Shi, X., Wang, S. H., Swanson, S. D., Ge, S., Cao, Z., Van Antwerp, M. E., Landmark, K. J. and Baker, J. R. (2008), Dendrimer-Functionalized Shell-crosslinked Iron Oxide Nanoparticles for In-Vivo Magnetic Resonance Imaging of Tumors. Adv. Mater., 20: 1671–1678. doi: 10.1002/adma.200702770

Author Information

  1. 1

    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA)

  2. 2

    Department of Radiology, University of Michigan, Ann Arbor, MI 48109 (USA)

  3. 3

    Department of Physics, University of Michigan, Ann Arbor, MI 48109 (USA)

*Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA).

  1. †

    X. Shi and S. H. Wang contributed equally to this work. This project has been funded in whole or in part by the National Institutes of Health (NIH) (under the contract # NIH 1 RO1 EB002657, NOI-CO-97111, and NIH 1 RO1 CA119409) and the Michigan Economic Development Corporation-Life Sciences Corridor Fund (under award GR-472). The authors thank Sasha Meshinchi for his assistance with the TEM experiments and valuable discussions. Supporting Information is available online from Wiley InterScience or from the author.

Publication History

  1. Issue published online: 5 MAY 2008
  2. Article first published online: 11 APR 2008
  3. Manuscript Revised: 14 DEC 2007
  4. Manuscript Received: 7 NOV 2007

Funded by

  • National Institutes of Health (NIH). Grant Numbers: # NIH 1 RO1 EB002657, NOI-CO-97111, NIH 1 RO1 CA119409
  • Michigan Economic Development Corporation-Life Sciences Corridor Fund

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Keywords:

  • dendrimers;
  • functionalization;
  • iron oxide;
  • magnetic resonance imaging;
  • metal nanoparticles
Thumbnail image of graphical abstract

A powerful magnetic nanoprobe with folic acid (FA)-targeting ligands is fabricated by dendrimer functionalization of Fe3O4 nanoparticles (NPs) precoated with crosslinkable and biocompatible polymer multilayer shells. This magnetic probe allows for magnetic resonance imaging of FA receptor-overexpressing tumor cells in vitro and of an early-stage tumor model in vivo (see picture).

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