Get access
Advanced Materials

Dendrimer-Functionalized Shell-crosslinked Iron Oxide Nanoparticles for In-Vivo Magnetic Resonance Imaging of Tumors

Authors

  • Xiangyang Shi,

    Corresponding author
    1. Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA)
    • Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA).
    Search for more papers by this author
  • Su He Wang,

    Corresponding author
    1. Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA)
    • Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA).
    Search for more papers by this author
  • Scott D. Swanson,

    1. Department of Radiology, University of Michigan, Ann Arbor, MI 48109 (USA)
    Search for more papers by this author
  • Song Ge,

    1. Department of Physics, University of Michigan, Ann Arbor, MI 48109 (USA)
    Search for more papers by this author
  • Zhengyi Cao,

    1. Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA)
    Search for more papers by this author
  • Mary E. Van Antwerp,

    1. Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA)
    Search for more papers by this author
  • Kevin J. Landmark,

    1. Department of Physics, University of Michigan, Ann Arbor, MI 48109 (USA)
    Search for more papers by this author
  • James R. Baker Jr

    Corresponding author
    1. Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA)
    • Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 (USA).
    Search for more papers by this author

  • X. Shi and S. H. Wang contributed equally to this work. This project has been funded in whole or in part by the National Institutes of Health (NIH) (under the contract # NIH 1 RO1 EB002657, NOI-CO-97111, and NIH 1 RO1 CA119409) and the Michigan Economic Development Corporation-Life Sciences Corridor Fund (under award GR-472). The authors thank Sasha Meshinchi for his assistance with the TEM experiments and valuable discussions. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

A powerful magnetic nanoprobe with folic acid (FA)-targeting ligands is fabricated by dendrimer functionalization of Fe3O4 nanoparticles (NPs) precoated with crosslinkable and biocompatible polymer multilayer shells. This magnetic probe allows for magnetic resonance imaging of FA receptor-overexpressing tumor cells in vitro and of an early-stage tumor model in vivo (see picture).

original image
Get access to the full text of this article

Ancillary