Electrical Detection of Femtomolar DNA via Gold-Nanoparticle Enhancement in Carbon-Nanotube-Network Field-Effect Transistors

Authors

  • Xiaochen Dong,

    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Ave., Singapore 637819 (Singapore)
    2. Institute of Advanced Materials Nanjing University of Posts and Telecommunications 9 Wenyuan Road, Nanjing 210046 (PR China)
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  • Ching Man Lau,

    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Ave., Singapore 637819 (Singapore)
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  • Anup Lohani,

    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Ave., Singapore 637819 (Singapore)
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  • Subodh G. Mhaisalkar,

    Corresponding author
    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Ave., Singapore 637819 (Singapore)
    • School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Ave., Singapore 637819 (Singapore).
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  • Johnson Kasim,

    1. School of Physical and Mathematical Science Nanyang Technological University Singapore 637371 (Singapore)
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  • Zexiang Shen,

    1. School of Physical and Mathematical Science Nanyang Technological University Singapore 637371 (Singapore)
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  • Xinning Ho,

    1. Department of Materials Science and Engineering Department of Chemistry University of Illinois at Urbana–Champaign Urbana, IL 61801 (USA)
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  • John A. Rogers,

    1. Department of Materials Science and Engineering Department of Chemistry University of Illinois at Urbana–Champaign Urbana, IL 61801 (USA)
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  • Lain-Jong Li

    Corresponding author
    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Ave., Singapore 637819 (Singapore)
    • School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Ave., Singapore 637819 (Singapore).
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  • This research was supported by Nanyang Technological University, Singapore.

Abstract

original image

A dramatic sensitivity enhancement in electrical detection of DNA hybridization using single-walled carbon nanotube networked field effect transistors (SNFETs) via introducing reporter DNA-Au nanoparticle (AuNP) conjugates in the hybridization step is reported. The amplified change in drain current allows to reliably determine the DNA concentration down to ∼100 fM.

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