Communication

Synthesis and Characterization of Iron Oxide Derivatized Mutant Cowpea Mosaic Virus Hybrid Nanoparticles†

  1. Alfredo A. Martinez-Morales2,
  2. Nathaniel G. Portney3,
  3. Yu Zhang1,
  4. Giuseppe Destito4,
  5. Gurer Budak5,
  6. Ekmel Ozbay6,
  7. Marianne Manchester4,
  8. Cengiz S. Ozkan1,*,
  9. Mihrimah Ozkan2,*

Article first published online: 27 AUG 2008

DOI: 10.1002/adma.200702863

Issue

Advanced Materials

Advanced Materials

Volume 20, Issue 24, pages 4816–4820, December 17, 2008

Additional Information

How to Cite

Martinez-Morales, A. A., Portney, N. G., Zhang, Y., Destito, G., Budak, G., Ozbay, E., Manchester, M., Ozkan, C. S. and Ozkan, M. (2008), Synthesis and Characterization of Iron Oxide Derivatized Mutant Cowpea Mosaic Virus Hybrid Nanoparticles. Adv. Mater., 20: 4816–4820. doi: 10.1002/adma.200702863

Author Information

  1. 1

    Department of Mechanical Engineering, University of California Riverside 92521 Riverside, CA (USA)

  2. 2

    Department of Electrical Engineering, University of California Riverside 92521 Riverside, CA (USA)

  3. 3

    Department of Bioengineering, University of California Riverside 92521 Riverside, CA (USA)

  4. 4

    Department of Cell Biology, The Scripps Research Institute 92037 La Jolla, CA (USA)

  5. 5

    Faculty of Medicine, Nanomedicine Research Laboratory, Gazi University 06510 Ankara (Turkey)

  6. 6

    Nanotechnology Research Center Department of Electrical and Electronics Engineering and Department of Physics Bilkent University 06800 Ankara (Turkey)

*Department of Mechanical Engineering, University of California Riverside 92521 Riverside, CA (USA).

  1. †

    This research was supported by the Center for Nanotechnology for the Treatment, Understanding and Monitoring of Cancer (NANOTUMOR) funded by the National Cancer Institute (NCI) and by the FCRP Center on Functional Engineered Nano Architectonics (FENA) funded by the Defense Advanced Research Projects Agency (DARPA) and the Semiconductor Research Corporation (SRC). The authors gratefully acknowledge Freida Dallal for technical assistance during FTIR studies and Nissim Amos for fruitful discussions on MFM imaging.

Publication History

  1. Issue published online: 16 DEC 2008
  2. Article first published online: 27 AUG 2008
  3. Manuscript Revised: 31 MAR 2008
  4. Manuscript Received: 18 NOV 2007

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Keywords:

  • CPMV;
  • functionalization;
  • iron oxide;
  • magnetic force microscopy;
  • self assembly
Thumbnail image of graphical abstract

A novel nanoparticle hybrid is attained by the covalent attachment of iron oxide (γ-Fe2O3) nanoclusters onto the surface of a mutagenized cow pea mosaic virus (CPMV-T184C). Using a stepwise substrate-based integration, monodisperse CPMV-IO hybrids are anchored on a gold substrate. The physical and magnetic properties of individual CPMV-IO hybrids are qualitatively investigated by atomic/magnetic force microscopy (AFM/ MFM). During MFM characterization a ‘boundary-effect’ is observed at the CPMV/IO interface.

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