Synthesis and Characterization of Iron Oxide Derivatized Mutant Cowpea Mosaic Virus Hybrid Nanoparticles


  • This research was supported by the Center for Nanotechnology for the Treatment, Understanding and Monitoring of Cancer (NANOTUMOR) funded by the National Cancer Institute (NCI) and by the FCRP Center on Functional Engineered Nano Architectonics (FENA) funded by the Defense Advanced Research Projects Agency (DARPA) and the Semiconductor Research Corporation (SRC). The authors gratefully acknowledge Freida Dallal for technical assistance during FTIR studies and Nissim Amos for fruitful discussions on MFM imaging.


original image

A novel nanoparticle hybrid is attained by the covalent attachment of iron oxide (γ-Fe2O3) nanoclusters onto the surface of a mutagenized cow pea mosaic virus (CPMV-T184C). Using a stepwise substrate-based integration, monodisperse CPMV-IO hybrids are anchored on a gold substrate. The physical and magnetic properties of individual CPMV-IO hybrids are qualitatively investigated by atomic/magnetic force microscopy (AFM/ MFM). During MFM characterization a ‘boundary-effect’ is observed at the CPMV/IO interface.