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Hierarchical Assembly of Multilayered Hollow Microspheres from an Amphiphilic Pharmaceutical Molecule of Azithromycin

Authors

  • Hong Zhao,

    1. Key Lab for Nanomaterials, Ministry of Education Beijing University of Chemical Technology Beijing 100029 (PR China)
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  • Jian-Feng Chen,

    Corresponding author
    1. Key Lab for Nanomaterials, Ministry of Education Beijing University of Chemical Technology Beijing 100029 (PR China)
    • Key Lab for Nanomaterials, Ministry of Education Beijing University of Chemical Technology Beijing 100029 (PR China).
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  • Yong Zhao,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS) Organic Solid Laboratory of Center for Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences Beijing 100080 (PR China)
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  • Lei Jiang,

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences (BNLMS) Organic Solid Laboratory of Center for Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences Beijing 100080 (PR China)
    • Beijing National Laboratory for Molecular Sciences (BNLMS) Organic Solid Laboratory of Center for Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences Beijing 100080 (PR China).
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  • Jing-Wei Sun,

    1. Key Lab for Nanomaterials, Ministry of Education Beijing University of Chemical Technology Beijing 100029 (PR China)
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  • Jimmy Yun

    1. Nanomaterial Technology Pte. Ltd Singapore, 139959 (Singapore)
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  • This work was supported by the National Natural Science Foundation of China (No.50642042). Supporting Information is available online at Wiley InterScience or from the author.

Abstract

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Hollow microspheres with multilayered porous shells are formed by a template-free method by hierarchical assembly of azithromycin molecules. This simple, rapid, and high-yielding method allows the number of layers to be tailored by regulating the initial concentration of azithromycin solution. Such structures may find applications in controlled drug delivery amongst other fields.

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