We gratefully acknowledge the support of the EPSRC (EP/E007627/1) and The Leverhulme Trust.
Enzyme-Responsive Nanoparticle Systems†
Article first published online: 2 JUN 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 20, Issue 22, pages 4359–4363, November 18, 2008
How to Cite
Ghadiali, J. E. and Stevens, M. M. (2008), Enzyme-Responsive Nanoparticle Systems. Adv. Mater., 20: 4359–4363. doi: 10.1002/adma.200703158
- Issue published online: 13 NOV 2008
- Article first published online: 2 JUN 2008
- inorganic nanoparticles;
- stimuli-responsive materials
Inorganic nanoparticles and their accompanying diverse physical properties are now virtually in routine use as imaging tools in cell-biology. In addition to serving as excellent contrast agents, their size- and environment-dependent optical and magnetic properties can be harnessed to create enzyme biosensor devices of extremely high sensitivity, whilst circumventing the numerous technical limitations associated with traditional enzyme assays. In this Research News article we discuss recent advances in field of enzyme-responsive nanoparticle systems, where the activity of an enzyme elicits a specific response in the nanoparticle assembly to produce a signal relating to enzyme activity, focusing on three important systems: DNA-structured nanoparticles, protein kinases and proteases.