1521-4095/asset/olbannercenter.gif?v=1&s=529a7434a29cae1cc1d6c7ab89395d70e2677ce1)
Inside Front Cover
Inside Front Cover: Modulating Neuronal Responses by Controlled Integration of Acetylcholine-like Functionalities in Biomimetic Polymers (Adv. Mater. 24/2007)
Article first published online: 11 DEC 2007
DOI: 10.1002/adma.200790100
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Gumera, C. and Wang, Y. (2007), Inside Front Cover: Modulating Neuronal Responses by Controlled Integration of Acetylcholine-like Functionalities in Biomimetic Polymers (Adv. Mater. 24/2007). Advanced Materials, 19: n/a. doi: 10.1002/adma.200790100
Publication History
- Issue published online: 11 DEC 2007
- Article first published online: 11 DEC 2007
- Abstract
- Cited By
Keywords:
- Biomaterials;
- Biomimetics;
- Bioploymers;
- Neurons
Graphical Abstract
This paper describes a new pathway to neuroactive materials that relies on integration of neurotransmitter-like functional groups into synthetic polymers. A series of biodegradable polymers are synthesized with varying concentrations of acetylcholine-like functionalities (ALFs) using a modular design. The polymers with medium ALF contents resemble laminin in promoting neurite sprouting and extension while maintaining phenotypic protein expression of neurons.
Abstract
Primary neurons respond to acetylcholine functionalities in polymers in a dose-dependent manner, report Christiane Gumera and Yadong Wang on p. 4404. The control of the interactions between a biomaterial and neurons may enable novel clinical treatments for neurological disorders. Here, the repeating unit of the polymer is shown on top of neurites extending from the dorsal root ganglia cultured on the polymer.