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Keywords:

  • Bionanotechnology;
  • Iron oxide;
  • Nanoparticles;
  • Cells;
  • Drug delivery
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The synthesis, in vitro, and in vivo behavior of tumor-homing magnetic nanoworms (NW) are described. The particles consist of a chainlike aggregation of iron oxide (IO) cores in a dextran coating. When conjugated with a tumor-targeting peptide, they interact more effectively with a tumor-based target in vitro relative to spherical nanoparticles. Untargeted NW display similar in vivo circulation times and enhanced passive accumulation in mouse xenograft tumors relative to untargeted spherical IO nanoparticles.