Nano- and Micropatterning of Optically Transparent, Mechanically Robust, Biocompatible Silk Fibroin Films


  • This work was supported by the DARPA, AFOSR, Tufts School of Engineering, and by the College of Engineering Dean's Catalyst Award at Boston University. The authors would like to thank Jessica Wargats of Digital Optics Inc./Tessera. for the diffractive optics sample.


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Regular nanometer-scale patterning down to a few tens of nanometers and the manufacturing of diffractive optical elements in silk by using the ideas of soft lithography is reported. The unique processing of silk films makes them an ideal substrate to incorporate biological matter (such as small organics, enzymes, proteins, cells). Unprecedented definition in the transverse direction, with features down to few tens of nanometers, is reported.