This research was supported by the Intramural Research Program of the Clinical Center at the National Institutes of Health. The authors would like to acknowledge the help of Dr. Leapman for TEM analysis. Supporting Information is available online from Wiley InterScience or from the authors.
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Communication
Synthesis of Complexable Fluorescent Superparamagnetic Iron Oxide Nanoparticles (FL SPIONs) and Cell Labeling for Clinical Application†
Article first published online: 2 JUN 2008
DOI: 10.1002/adma.200800223
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Lee, J.-H., Schneider, B., Jordan, E. K., Liu, W. and Frank, J. A. (2008), Synthesis of Complexable Fluorescent Superparamagnetic Iron Oxide Nanoparticles (FL SPIONs) and Cell Labeling for Clinical Application. Advanced Materials, 20: 2512–2516. doi: 10.1002/adma.200800223
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Publication History
- Issue published online: 8 JUL 2008
- Article first published online: 2 JUN 2008
- Manuscript Received: 23 JAN 2008
Keywords:
- biotechnology;
- fluorescent probes;
- hybrid materials;
- imaging agents;
- nanotechnology
Graphical Abstract
We describe a new synthesis route for fluorescent superparamagnetic iron oxide nanoparticles (FL SPIONs) and the self-assembled complex formed using FL SPION and protamine sulfate for cell labeling. This synthesis route involves the conjugation of the FDA-approved dextran-coated ferumoxides with fluorescent dextran. The novel nanostructure of FL SPION is stable in vitro and it complexes with a cationic peptide.