PEGylated Calcium Phosphate Nanocomposites as Smart Environment-Sensitive Carriers for siRNA Delivery

Authors

  • Mingzhen Zhang,

    1. Department of Materials Engineering Graduate School of Engineering The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan)
    2. School of Ophthalmology and Optometry Wenzhou Medical College Wenzhou, Zhejiang 325027 (P.R. China)
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  • Atsushi Ishii,

    1. Department of Materials Engineering Graduate School of Engineering The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan)
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  • Nobuhiro Nishiyama,

    1. Division of Clinical Biotechnology Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 (Japan)
    2. Center for NanoBio Integration The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan)
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  • Satoru Matsumoto,

    1. Department of Materials Engineering Graduate School of Engineering The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan)
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  • Takehiko Ishii,

    1. Department of Materials Engineering Graduate School of Engineering The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan)
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  • Yuichi Yamasaki,

    1. Department of Materials Engineering Graduate School of Engineering The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan)
    2. Center for NanoBio Integration The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan)
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  • Kazunori Kataoka

    Corresponding author
    1. Department of Materials Engineering Graduate School of Engineering The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan)
    2. Division of Clinical Biotechnology Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 (Japan)
    3. Center for NanoBio Integration The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan)
    • Department of Materials Engineering Graduate School of Engineering The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 (Japan).
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Abstract

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A novel inorganic–organic hybrid nanocomposite is formed in situ using a simple and straightforward method. Conjugate of short interfering RNA (siRNA) duplex with poly(ethylene glycol) via a disulfide linkage (PEG–SS–siRNA) is demonstrated to regulate the crystal growth of calcium phosphate (CaP), yielding a monodispersed nanocomposite. The resultant nanocomposite can be utilized as nanocarriers for siRNA delivery.

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