Bifunctional Fe3O4–Ag Heterodimer Nanoparticles for Two-Photon Fluorescence Imaging and Magnetic Manipulation


  • The authors thank Dr. Yu Han and Dr. Lan Zhao, Dr. Shyh-Chyang Luo, and Chiang Huen Kang for their assistance with TEM, inductively coupled plasma-mass spectrometry (ICP-MS), and two-photon fluorescence microscopy, respectively. This work is funded by the Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore). G. C. P. thanks the National Science Foundation and the European Union, Marie Curie Program, for support. Supporting information is available online from Wiley InterScience or from the authors.


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Fe3O4–Ag heterodimer nanocomposites of tunable sizes are synthesized with high yield under mild conditions, without the loss of high magnetic moment. A ligand-exchange scheme is devised utilizing the bifunctionality of the heterodimer system to render the nanocomposite soluble in aqueous solutions. Cells labeled with the heterodimer nanoparticles can be magnetically manipulated and imaged with two-photon fluorescence microscopy.