Communication

In vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy

  1. Hsiung-Lin Tu1,
  2. Yu-Shen Lin1,
  3. Hsia-Yu Lin2,
  4. Yann Hung1,
  5. Leu-Wei Lo3,
  6. Yang-Fang Chen2,
  7. Chung-Yuan Mou1,*

Article first published online: 2 JAN 2009

DOI: 10.1002/adma.200800548

Issue

Advanced Materials

Advanced Materials

Volume 21, Issue 2, pages 172–177, January 12, 2009

Additional Information

How to Cite

Tu, H.-L., Lin, Y.-S., Lin, H.-Y., Hung, Y., Lo, L.-W., Chen, Y.-F. and Mou, C.-Y. (2009), In vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy. Adv. Mater., 21: 172–177. doi: 10.1002/adma.200800548

Author Information

  1. 1

    Department of Chemistry, National Taiwan University Taipei 106 (Taiwan)

  2. 2

    Department of Physics, National Taiwan University Taipei 106 (Taiwan)

  3. 3

    Division of Medical Engineering Research, National Health Research Institute Zhunan 350 (Taiwan)

*Department of Chemistry, National Taiwan University Taipei 106 (Taiwan).

Publication History

  1. Issue published online: 2 JAN 2009
  2. Article first published online: 2 JAN 2009
  3. Manuscript Revised: 28 MAY 2008
  4. Manuscript Received: 26 FEB 2008

Funded by

  • National Science Council of Taiwan. Grant Number: NSC 95-2120-M-002-009

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Keywords:

  • biomedical materials;
  • mesoporous materials;
  • photodynamic therapy;
  • silica nanoparticles
Thumbnail image of graphical abstract

A versatile platform for photodynamic therapy (PDT), mesoporous silica nanoparticles functionalized with protoporphyrin IX (PpIX-MSNs), has been developed. In vitro studies on HeLa cells show high uptake efficiency. Phototoxicity results give both irradiation time- and dosage-dependent cell death events. Because of the ease of incorporating other biomedical functional groups, we believe MSNs would be an ideal platform for biomedical applications.

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