Microcapsules Containing a Biomolecular Motor for ATP Biosynthesis

Authors

  • Qiang He,

    1. Beijing National Laboratory for Molecular Science, International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 (China)
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  • Li Duan,

    1. Beijing National Laboratory for Molecular Science, International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 (China)
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  • Wei Qi,

    1. Beijing National Laboratory for Molecular Science, International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 (China)
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  • Kewei Wang,

    1. Beijing National Laboratory for Molecular Science, International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 (China)
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  • Yue Cui,

    1. Beijing National Laboratory for Molecular Science, International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 (China)
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  • Xuehai Yan,

    1. Beijing National Laboratory for Molecular Science, International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 (China)
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  • Junbai Li

    Corresponding author
    1. Beijing National Laboratory for Molecular Science, International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 (China)
    • Beijing National Laboratory for Molecular Science, International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 (China).
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  • This work was financially supported by the National Nature Science Foundation of China (No. 20520130213), National Basic Research Program of China (973 program) 2007CB935900 as well as the Chinese Academy of Sciences. The authors are grateful to Prof. Möhwald for valuable discussion and consistent support.

Abstract

Over the past two decades, advances in modern biology and nanotechnology have enabled a rapid development in the design and building of biomimetic functional materials. ATP synthase is one of the most extensively studied molecular machines because it can be used as a rotary motor in the design of novel nanodevices and it can also continuously synthesize ATP in an artificial environment. A lot of research efforts have focused on assembling ATP synthase in biomimetic systems so that a complex cellular process can be constructed in a controllable manner. As we summarize here, layer-by-layer assembled microcapsules have proved to be a suitable cellular mimetic structure, which can be applied for engineering active biomimetic systems with a cellular process. An added benefit is that these assembled microcapsules can be used as bioenergy containers and thus ATP supply on demand.

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