Fluorescent Conjugated Polyelectrolytes for Biomacromolecule Detection

Authors

  • Fude Feng,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
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  • Fang He,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
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  • Lingling An,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
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  • Shu Wang,

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
    • Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China).
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  • Yuliang Li,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
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  • Daoben Zhu

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China)
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  • This work is supported by the ‘100 Talents’ program of the Chinese Academy of Sciences, the National Natural Science Foundation of China (No. 20725308).

Abstract

Water-soluble conjugated polymers have attracted much attention in the biosensor community because of recent exciting experimental results. The transfer of excitation energy along the whole backbone of the conjugated polymer to the reporter results in an amplified fluorescence signal, which makes them useful as optical platforms in highly sensitive chemical and biological sensors. In this Research News Article, we provide a brief review of recent developments in this field, focusing especially on the application of water-soluble optical conjugated polymers in biomacromolecule (DNA and protein) detection.

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