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Multivalent, Saccharide-Functionalized Gold Nanoparticles as Fully Synthetic Analogs of Type A Neisseria meningitidis Antigens

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  • This work was supported by MUR via contract 2006039071 (PRIN 2006 to P.S.). The authors are indebted to Prof. A. Marigo and Dr. V. Causin for TGA analyses. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

Antigen analogs of polyclonal antibodies specific for type A Neisseria mengitidis are prepared by covering gold clusters (2–5 nm in size) with a monolayer of saccharides that have the structure of the repeating unit of the capsular polysaccharide of this bacterium. These systems may find use as synthetic antigens for immunostimulation.

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