Communication

Bioinspired Surface Immobilization of Hyaluronic Acid on Monodisperse Magnetite Nanocrystals for Targeted Cancer Imaging†

  1. Yuhan Lee1,
  2. Haeshin Lee2,
  3. Young Beom Kim3,
  4. Jaeyoon Kim4,
  5. Taeghwan Hyeon4,
  6. HyunWook Park3,
  7. Phillip B. Messersmith2,
  8. Tae Gwan Park1,*

Article first published online: 6 OCT 2008

DOI: 10.1002/adma.200800756

Issue

Advanced Materials

Advanced Materials

Volume 20, Issue 21, pages 4154–4157, November 3, 2008

Additional Information

How to Cite

Lee, Y., Lee, H., Kim, Y. B., Kim, J., Hyeon, T., Park, H., Messersmith, P. B. and Park, T. G. (2008), Bioinspired Surface Immobilization of Hyaluronic Acid on Monodisperse Magnetite Nanocrystals for Targeted Cancer Imaging. Adv. Mater., 20: 4154–4157. doi: 10.1002/adma.200800756

Author Information

  1. 1

    Department of Biological Sciences, Korea Advanced Institute of Science and Technology Daejeon 305-701 (Korea)

  2. 2

    Department of Biomedical Engineering, Northwestern University Evanston, Illinois 60208 (USA)

  3. 3

    Division of Electrical Engineering, School of Electrical Engineering and Computer Science Korea Advanced Institute of Science and Technology Daejeon 305-701 (Korea)

  4. 4

    School of Chemical and Biological Engineering, Seoul National University Seoul 151-744 (Korea)

*Department of Biological Sciences, Korea Advanced Institute of Science and Technology Daejeon 305-701 (Korea).

  1. †

    This work was supported by the National Research Laboratory program from the Ministry of Science and Technology, Republic of Korea. Supporting Information is available online from Wiley InterScience or from the authors.

Publication History

  1. Issue published online: 29 OCT 2008
  2. Article first published online: 6 OCT 2008
  3. Manuscript Revised: 18 MAY 2008
  4. Manuscript Received: 18 MAR 2008

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Keywords:

  • biomedical materials;
  • magnetic nanoparticles;
  • magnetic resonance;
  • targeted cancer imaging
Thumbnail image of graphical abstract

Hyaluronic-acid immobilized monodisperse magnetic nanocrystals (HA-DN/MNCs) are synthesized. Dopamine, the analogue of 3,4-dihydroxy-L-phenylalanine responsible for the adhesion properties in proteins excreted by mussels, plays a key role in the surface modification of nanocrystals. HA-DN/MNCs exhibit great stability in aqueous solution, applicable for in vivo targeted-cancer imaging.

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