This work was supported by the National Research Laboratory program from the Ministry of Science and Technology, Republic of Korea. Supporting Information is available online from Wiley InterScience or from the authors.
Bioinspired Surface Immobilization of Hyaluronic Acid on Monodisperse Magnetite Nanocrystals for Targeted Cancer Imaging†
Article first published online: 6 OCT 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 20, Issue 21, pages 4154–4157, November 3, 2008
How to Cite
Lee, Y., Lee, H., Kim, Y. B., Kim, J., Hyeon, T., Park, H., Messersmith, P. B. and Park, T. G. (2008), Bioinspired Surface Immobilization of Hyaluronic Acid on Monodisperse Magnetite Nanocrystals for Targeted Cancer Imaging. Adv. Mater., 20: 4154–4157. doi: 10.1002/adma.200800756
- Issue published online: 29 OCT 2008
- Article first published online: 6 OCT 2008
- Manuscript Revised: 18 MAY 2008
- Manuscript Received: 18 MAR 2008
- biomedical materials;
- magnetic nanoparticles;
- magnetic resonance;
- targeted cancer imaging
Hyaluronic-acid immobilized monodisperse magnetic nanocrystals (HA-DN/MNCs) are synthesized. Dopamine, the analogue of 3,4-dihydroxy-L-phenylalanine responsible for the adhesion properties in proteins excreted by mussels, plays a key role in the surface modification of nanocrystals. HA-DN/MNCs exhibit great stability in aqueous solution, applicable for in vivo targeted-cancer imaging.