Financial support was provided by the Arnold and Mabel Beckman Foundation, the National Institutes of Health (EB002746 and EB006820), and the University of Wisconsin. We are grateful to the NSF (CHE-9208463) and the NIH (NIH 1 S10 RR0 8389-01) for support of the UW NMR spectroscopy facilities. D. M. L. is an Alfred P. Sloan Research Fellow. Supporting Information is available online from Wiley InterScience or from the authors.
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Communication
Ultrathin Multilayered Films that Promote the Release of Two DNA Constructs with Separate and Distinct Release Profiles†
Article first published online: 6 OCT 2008
DOI: 10.1002/adma.200800881
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Liu, X., Zhang, J. and Lynn, D. M. (2008), Ultrathin Multilayered Films that Promote the Release of Two DNA Constructs with Separate and Distinct Release Profiles. Adv. Mater., 20: 4148–4153. doi: 10.1002/adma.200800881
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Publication History
- Issue published online: 29 OCT 2008
- Article first published online: 6 OCT 2008
- Manuscript Revised: 3 JUN 2008
- Manuscript Received: 31 MAR 2008
Funded by
- Arnold and Mabel Beckman Foundation
- National Institutes of Health. Grant Numbers: EB002746, EB006820
Keywords:
- biomedical materials;
- controlled release;
- DNA;
- drug delivery;
- polymeric materials;
- thin films
‘Charge-shifting’ cationic polymers are used to fabricate ultrathin multilayered films that promote the release of two different DNA constructs with separate and essentially nonoverlapping release profiles. This approach could contribute to the development of thin films and functional coatings capable of regulating the localized release of different DNA constructs (or other agents) to cells or tissues in a broad range of fundamental and applied contexts.