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Advanced Materials

Ultrathin Multilayered Films that Promote the Release of Two DNA Constructs with Separate and Distinct Release Profiles

Authors

  • Xianghui Liu,

    1. Department of Chemical and Biological Engineering, University of Wisconsin – Madison 1415 Engineering Drive, Madison, WI 53706 (USA)
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  • Jingtao Zhang,

    1. Department of Chemical and Biological Engineering, University of Wisconsin – Madison 1415 Engineering Drive, Madison, WI 53706 (USA)
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  • David M. Lynn

    Corresponding author
    1. Department of Chemical and Biological Engineering, University of Wisconsin – Madison 1415 Engineering Drive, Madison, WI 53706 (USA)
    • Department of Chemical and Biological Engineering, University of Wisconsin – Madison 1415 Engineering Drive, Madison, WI 53706 (USA).
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  • Financial support was provided by the Arnold and Mabel Beckman Foundation, the National Institutes of Health (EB002746 and EB006820), and the University of Wisconsin. We are grateful to the NSF (CHE-9208463) and the NIH (NIH 1 S10 RR0 8389-01) for support of the UW NMR spectroscopy facilities. D. M. L. is an Alfred P. Sloan Research Fellow. Supporting Information is available online from Wiley InterScience or from the authors.

Abstract

‘Charge-shifting’ cationic polymers are used to fabricate ultrathin multilayered films that promote the release of two different DNA constructs with separate and essentially nonoverlapping release profiles. This approach could contribute to the development of thin films and functional coatings capable of regulating the localized release of different DNA constructs (or other agents) to cells or tissues in a broad range of fundamental and applied contexts.

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