Enhancing the Toxicity of Cancer Chemotherapeutics with Gold Nanorod Hyperthermia

Authors

  • Tanya S. Hauck,

    1. Institute of Biomaterials and Biomedical Engineering, Materials Science and Engineering, Chemical Engineering and Applied Chemistry Terrence Donnelly Center for Cellular and Biomolecular Research University of Toronto 160 College Street, 4th Floor, Toronto, ON M5S 3G9 (Canada)
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  • Travis L. Jennings,

    1. Institute of Biomaterials and Biomedical Engineering, Materials Science and Engineering, Chemical Engineering and Applied Chemistry Terrence Donnelly Center for Cellular and Biomolecular Research University of Toronto 160 College Street, 4th Floor, Toronto, ON M5S 3G9 (Canada)
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  • Tetyana Yatsenko,

    1. Department of Physics Ryerson University 350 Victoria Street, Toronto, ON M5B 2K3 (Canada)
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  • J. Carl Kumaradas,

    1. Department of Physics Ryerson University 350 Victoria Street, Toronto, ON M5B 2K3 (Canada)
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  • Warren C. W. Chan

    Corresponding author
    1. Institute of Biomaterials and Biomedical Engineering, Materials Science and Engineering, Chemical Engineering and Applied Chemistry Terrence Donnelly Center for Cellular and Biomolecular Research University of Toronto 160 College Street, 4th Floor, Toronto, ON M5S 3G9 (Canada)
    • Institute of Biomaterials and Biomedical Engineering, Materials Science and Engineering, Chemical Engineering and Applied Chemistry Terrence Donnelly Center for Cellular and Biomolecular Research University of Toronto 160 College Street, 4th Floor, Toronto, ON M5S 3G9 (Canada).
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  • This project was financially supported by CIHR, NSERC, CFI, and OIT. We gratefully thank Dr. Chen Wang at Mt. Sinai Hospital for the OCI AML3 cells and Dr. Aaron Wheeler's laboratory (Univ. of Toronto) for the Jurkat T-Cells. The authors also thank Dionne White for help with flow cytometry and gratefully acknowledge the J. E. Davies laboratory (Univ. of Toronto) for use of their ViCell, the M. V. Sefton laboratory (Univ. of Toronto) for the use of their incubator, and Dr. William M. Whelan (Ryerson University) for use of his laser. T.H. thanks NSERC, CFUW, and the K. M. Hunter Foundation for funding. Supporting Information is available online from Wiley InterScience or from the authors.

Abstract

original image

The heat produced by optically excited gold nanorods is used to augment the chemotherapeutic agent cisplatin in killing tumor cells. This combined therapy kills 78% more cells than cisplatin alone, suggesting a synergistic interaction between these treatments.

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