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Keywords:

  • biomedical materials;
  • dip-pen lithography;
  • scanning probe microscopy;
  • tissue engineering peptides
Thumbnail image of graphical abstract

Dip-pen nanolithography is used to directly modify freshly dissected eye tissues with biologically active collagen-binding peptide molecules. The results address the challenge of surface heterogeneity and utilize dip-pen nanolithography to control the localization and concentration of molecules on a collagen-terminated tissue-derived surface. This method can allow the development of scaffolds for treatment of age-related macular degeneration.