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Nanopore-Spanning Lipid Bilayers for Controlled Chemical Release


  • This work was supported by the Arrowhead Research Corporation and the Bio-X Interdisciplinary Initiates Program. Supporting Information is available online from Wiley InterScience or from the authors.


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A hybrid organic/inorganic chemical delivery system with lipid bilayer seals is demonstrated. Semiconductor fabrication methods are used to produce chemical reservoirs with sub-micrometer pore openings. These openings are selectively sealed by depositing of lipid bilayers. The seals are leak-free and stable for weeks. When desired, the reservoirs can be opened with a standard microscope lamp.

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