Immunotargeting of Functional Nanoparticles for MRI detection of Apoptotic Tumor Cells


  • This work was supported by the International Science Linkages program established under the Australian Government's innovation statement Backing Australia's Ability, the Cancer Council South Australia, and NHMRC Project Grant ID511303.


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Hybrid MRI nanoprobes, immunotargeted to the La ribonucleoprotein, which becomes available for binding in the cytoplasm of post-apoptotic permeable cells, are designed for the improved detection of apoptotic tumor cells. The high level of specificity achieved through the use of an optimal polyethyleneglycol interlayer makes them excellent candidates for the in vivo detection of intratumoral apoptosis.