This work was supported by the International Science Linkages program established under the Australian Government's innovation statement Backing Australia's Ability, the Cancer Council South Australia, and NHMRC Project Grant ID511303.
Immunotargeting of Functional Nanoparticles for MRI detection of Apoptotic Tumor Cells†
Article first published online: 4 NOV 2008
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 21, Issue 5, pages 541–545, February 2, 2009
How to Cite
Thierry, B., Al-Ejeh, F., Brown, M. P., Majewski, P. and Griesser, H. J. (2009), Immunotargeting of Functional Nanoparticles for MRI detection of Apoptotic Tumor Cells. Adv. Mater., 21: 541–545. doi: 10.1002/adma.200800998
- Issue published online: 22 JAN 2009
- Article first published online: 4 NOV 2008
- Manuscript Revised: 7 JUL 2008
- Manuscript Received: 11 APR 2008
- Cancer Council South Australia
- NHMRC Project. Grant Number: ID511303
Hybrid MRI nanoprobes, immunotargeted to the La ribonucleoprotein, which becomes available for binding in the cytoplasm of post-apoptotic permeable cells, are designed for the improved detection of apoptotic tumor cells. The high level of specificity achieved through the use of an optimal polyethyleneglycol interlayer makes them excellent candidates for the in vivo detection of intratumoral apoptosis.