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Advanced Materials

Nanoporous Biodegradable Elastomers

Authors

  • Ryan A. Hoshi,

    1. Biomedical Engineering Department, Northwestern University 2145 Sheridan Road, Evanston, IL 60208 (USA)
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  • Saloni Behl,

    1. Biomedical Engineering Department, Northwestern University 2145 Sheridan Road, Evanston, IL 60208 (USA)
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  • Guillermo A. Ameer

    Corresponding author
    1. Biomedical Engineering Department, Northwestern University 2145 Sheridan Road, Evanston, IL 60208 (USA)
    2. Department of Surgery Northwestern University Feinberg School of Medicine 201 E Huron St., Chicago, IL 60611 (USA)
    3. The Institute for BioNanotechnology in Medicine Northwestern University 303 E. Superior, Chicago, IL 60611 (USA)
    • Biomedical Engineering Department, Northwestern University 2145 Sheridan Road, Evanston, IL 60208 (USA).
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  • This work was funded in part by Northwestern University's Materials Research Science and Engineering Center. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

A nanoporous biodegradable elastomer based on citric acid is described. Nanopores are used to control the mechanical and degradation properties of the elastomer. Furthermore, macromolecular drugs can be entrapped under mild conditions via pore collapse, which also delays the release of the drug. The nanoporous elastomer is biocompatible and a promising platform technology for engineering soft tissues.

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