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Keywords:

  • biomedical materials;
  • cell-specific delivery;
  • integrin;
  • nanoparticles;
  • protein cage
Thumbnail image of graphical abstract

Intracellular distribution of iron oxide nanoparticles incorporated within a ferritin mutant that displays genetically introduced cell-targeted peptides (RGD-4C) on its exterior surface are investigated using scanning transmission electron microscopy with a high-angle annular dark-field detector. The particles (indicated by arrows) internalized into macrophages much more effectively than those with noncell-targeted ferritin.