Highly Efficient Fluorescence of NdF3/SiO2 Core/Shell Nanoparticles and the Applications for in vivo NIR Detection


  • The authors thank the Natural Science Foundation of China and the National Program on Key Science Research (2006CB921500) for support. X.-F. Yu and L.-D. Chen contributed equally to this work. Supporting Information is available online from Wiley InterScience or from the authors.


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NdF3/SiO2 nanoparticles demonstrate highly efficient fluorescence due to successful suppressions of concentration quenching and surface quenching. More interestingly, their excitation and emission peaks with large frequency separation are both in the “near-infrared optical window” of biotissues. In living animal studies, the detecting depth can reach 1 cm by using a small dose of such nanomaterials.