Tailoring Bulk Transport in Hydrogels through Control of Polydispersity in the Nanoscale Pore Size Distribution


  • This work was supported in part by the National Institutes of Health under grants K22-HG02297 and R21-EB005965. We are especially grateful to Dr. Zhiping Luo and E. Ann Ellis in the Microscopy and Imaging Center at Texas A&M for their invaluable assistance with TEM measurements. We also thank Rodney Inmon and Prof. Dimitris Lagoudas in the Materials and Structures Laboratory, and Prof. Hung-Jue Sue in the Polymer Technology Center for assistance with and use of DSC instruments. We are also grateful to Prof. Michael Bevan for use of the MCR-300 rheometer.


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The average pore size and pore-size distributions of polymer hydrogels are quantified by a new approach, allowing us to show how composition and polymerization conditions shape the nanoporous morphology, and how the nanoscale distribution of pore sizes (polydispersity) plays a key role in governing the controlled release of macromolecules from hydrogel carriers.