Physics of Nanomechanical Biosensing on Cantilever Arrays


  • M.L.S., J.H.H. and A.L.S. thank the EPSRC for funding under the ‘Materials Modelling Initiative’ programme. M.W. and R.McK. thank Christoph Gerber, Hans Peter Lang (University of Basel), and IBM Rüschlikon for cantilever preparation facilities, Gabriel Aeppli and Jane Galbraith (University College London) for helpful discussions, and the Overseas Research Scholarship, the IRC in Nanotechnology (Cambridge, UCL and Bristol), EPSRC Speculative Engineering for funding. Supporting Information is available online from Wiley InterScience or from the authors.


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A quantitative model of nanomechanical biosensing, which links mesoscopic response of the BioMEMS device to specific chemical, elastic and entropic properties at the nanoscale, is reported (see figure). These concepts envision novel surface chemistries and device geometries ‘in silico’ with significantly improved detection sensitivities for nanomechanical biosensing.