Protein–Polymer Hybrid Amphiphiles

Authors

  • A. (Ton) J. Dirks,

    1. Institute for Molecules and Materials, Radboud University Nijmegen Toernooiveld 1, 6525 ED Nijmegen (The Netherlands)
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  • Roeland J. M. Nolte,

    1. Institute for Molecules and Materials, Radboud University Nijmegen Toernooiveld 1, 6525 ED Nijmegen (The Netherlands)
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  • Jeroen J. L. M. Cornelissen

    Corresponding author
    1. Institute for Molecules and Materials, Radboud University Nijmegen Toernooiveld 1, 6525 ED Nijmegen (The Netherlands)
    • Institute for Molecules and Materials, Radboud University Nijmegen Toernooiveld 1, 6525 ED Nijmegen (The Netherlands).
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  • The authors gratefully acknowledge the NRSC-Catalysis, the Chemical Council of The Netherlands Organization for Scientific Research (CW-NWO), and the Royal Netherlands Academy of Arts and Sciences for financial support.

Abstract

Biohybrid amphiphiles composed of a protein head group and a hydrophobic polymer tail self-assemble in water in a similar way as low molecular weight surfactants. Owing to the presence of the protein, biohybrid amphiphiles, and their assemblies, however, hold the additional feature of a built-in (bio)functionality. These compounds therefore are promising building blocks for the synthesis of functional nanometer-sized materials. We discuss recent advances in the relatively young field of protein–polymer hybrid amphiphiles, which so far mainly involved exploratory and fundamental studies providing a conceptual basis for the development of more complex systems with interesting applications in the future.

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