A Materials Approach to the Dual-Site Isolation of Catalysts Bonded to Linear Polymers and Small, Ionic Molecules for Use in One-Pot Cascade Reactions


  • The authors gratefully acknowledge the Research Corporation for a Research Innovation Award, the Roy J. Carver Charitable Trust, and the National Science Foundation for research funds (DMR 0734158). We also thank M. Brett Runge for supplying polystyrene and Santhana Velupillai for help determining the molecular weight of LPDMAP. Supporting Information is available online from Wiley InterScience or from the author.


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Site isolation of ionic catalysts and polymer-bound catalysts is achieved by placement on different sides of PDMS membranes. Ionic molecules and polymers do not flux through the PDMS membranes, but organic molecules can flux through the membranes and react with catalysts that are incompatible with each other. This is a general approach to site-isolate catalysts from each other.