Integrating Biosensors and Drug Delivery: A Step Closer Toward Scalable Responsive Drug-Delivery Systems

Authors

  • Han-Kuan Anthony Tsai,

    1. BioMEMS Research Group Mechanical and Aerospace Engineering Department University of California, Irvine 4200 Engineering Gateway, Irvine, CA 92697-3975 (USA)
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  • Elizabeth A. Moschou,

    1. Department of Chemistry, University of Kentucky Lexington, KY 40506-0055 (USA)
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  • Sylvia Daunert,

    1. Department of Chemistry, University of Kentucky Lexington, KY 40506-0055 (USA)
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  • Marc Madou,

    1. BioMEMS Research Group Mechanical and Aerospace Engineering Department University of California, Irvine 4200 Engineering Gateway, Irvine, CA 92697-3975 (USA)
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  • Lawrence Kulinsky

    Corresponding author
    1. BioMEMS Research Group Mechanical and Aerospace Engineering Department University of California, Irvine 4200 Engineering Gateway, Irvine, CA 92697-3975 (USA)
    • BioMEMS Research Group Mechanical and Aerospace Engineering Department University of California, Irvine 4200 Engineering Gateway, Irvine, CA 92697-3975 (USA).
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Abstract

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A miniature biosensor immobilized on the backside of a gold lid is protected inside a microfabricated vial. To activate the protected biosensor, the conjugated polymer/gold lid is opened by the application of 800 mV. Both independent sensing and drug delivery from the microvalves are demonstrated.

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