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Exploring Optical Properties of Liquid Crystals for Developing Label-Free and High-Throughput Microfluidic Immunoassays†

  1. Chang-Ying Xue,
  2. Saif A. Khan,
  3. Kun-Lin Yang*

Article first published online: 4 NOV 2008

DOI: 10.1002/adma.200801803

Issue

Advanced Materials

Advanced Materials

Volume 21, Issue 2, pages 198–202, January 12, 2009

Additional Information

How to Cite

Xue, C.-Y., Khan, S. A. and Yang, K.-L. (2009), Exploring Optical Properties of Liquid Crystals for Developing Label-Free and High-Throughput Microfluidic Immunoassays. Adv. Mater., 21: 198–202. doi: 10.1002/adma.200801803

Author Information

  1. Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4, Singapore 117576 (Singapore)

*Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4, Singapore 117576 (Singapore).

  1. †

    We would like to thank Suhanya Duraiswamy and Pravien Parthiban for their assistance in master fabrication and initial device-molding experiments.

Publication History

  1. Issue published online: 2 JAN 2009
  2. Article first published online: 4 NOV 2008
  3. Manuscript Revised: 9 AUG 2008
  4. Manuscript Received: 28 JUN 2008

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Keywords:

  • immunoassays;
  • liquid crystals;
  • microfluidics;
  • thin films
Thumbnail image of graphical abstract

The orientational transition of liquid crystals (LCs) is used as a label-free detection mechanism for immunoassays developed in microfluidic systems. LCs only show bright optical textures (visible to the naked eye) in the line-line intersections in which label-free antibodies bind to their surface-immobilized antigens, suggesting the feasibility of using LCs to detect specific antigen-antibody binding events in a high-throughput and multiplexed manner.

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