Mineral-Coated Polymer Microspheres for Controlled Protein Binding and Release

Authors

  • Leenaporn Jongpaiboonkit,

    1. Department of Biomedical Engineering University of Wisconsin 1550 Engineering Drive, Madison, WI 53706 (USA)
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  • Travelle Franklin-Ford,

    1. Department of Biomedical Engineering University of Wisconsin 1550 Engineering Drive, Madison, WI 53706 (USA)
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  • William L. Murphy

    Corresponding author
    1. Department of Biomedical Engineering University of Wisconsin 1550 Engineering Drive, Madison, WI 53706 (USA)
    2. Department of Pharmacology, University of Wisconsin Madison, WI 53706 (USA)
    3. Department of Materials Science and Engineering University of Wisconsin Madison, WI 53706 (USA)
    • Department of Biomedical Engineering University of Wisconsin 1550 Engineering Drive, Madison, WI 53706 (USA).
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Abstract

original image

Polymer microspheres with a bone-like mineral coatings are generated via a biomimetic process, and this biodegradable coating is used as a carrier for delivery of biological molecules. Acidic and basic proteins are controllably bound and released from these microspheres, suggesting that this approach can be used for binding and delivery of a broad range of biologically active molecules.

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