Communication

Mineral-Coated Polymer Microspheres for Controlled Protein Binding and Release

  1. Leenaporn Jongpaiboonkit1,
  2. Travelle Franklin-Ford1,
  3. William L. Murphy1,2,3,*

Article first published online: 27 FEB 2009

DOI: 10.1002/adma.200801808

Issue

Advanced Materials

Advanced Materials

Volume 21, Issue 19, pages 1960–1963, May 18, 2009

Additional Information

How to Cite

Jongpaiboonkit, L., Franklin-Ford, T. and Murphy, W. L. (2009), Mineral-Coated Polymer Microspheres for Controlled Protein Binding and Release. Adv. Mater., 21: 1960–1963. doi: 10.1002/adma.200801808

Author Information

  1. 1

    Department of Biomedical Engineering University of Wisconsin 1550 Engineering Drive, Madison, WI 53706 (USA)

  2. 2

    Department of Pharmacology, University of Wisconsin Madison, WI 53706 (USA)

  3. 3

    Department of Materials Science and Engineering University of Wisconsin Madison, WI 53706 (USA)

*Department of Biomedical Engineering University of Wisconsin 1550 Engineering Drive, Madison, WI 53706 (USA).

Publication History

  1. Issue published online: 12 MAY 2009
  2. Article first published online: 27 FEB 2009
  3. Manuscript Revised: 2 DEC 2008
  4. Manuscript Received: 29 JUN 2008

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Keywords:

  • controlled release;
  • drug delivery;
  • mineralization;
  • PLG microsphere
Thumbnail image of graphical abstract

Polymer microspheres with a bone-like mineral coatings are generated via a biomimetic process, and this biodegradable coating is used as a carrier for delivery of biological molecules. Acidic and basic proteins are controllably bound and released from these microspheres, suggesting that this approach can be used for binding and delivery of a broad range of biologically active molecules.

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