Communication

Binding, Internalization, and Antigen Presentation of Vaccine-Loaded Nanoengineered Capsules in Blood†

  1. Robert De Rose1,2,
  2. Alexander N. Zelikin1,
  3. Angus P. R. Johnston1,
  4. Amy Sexton2,
  5. Siow-Feng Chong1,
  6. Christina Cortez1,
  7. William Mulholland1,
  8. Frank Caruso1,*,
  9. Stephen J. Kent2,*

Article first published online: 17 OCT 2008

DOI: 10.1002/adma.200801826

Issue

Advanced Materials

Advanced Materials

Volume 20, Issue 24, pages 4698–4703, December 17, 2008

Additional Information

How to Cite

De Rose, R., Zelikin, A. N., Johnston, A. P. R., Sexton, A., Chong, S.-F., Cortez, C., Mulholland, W., Caruso, F. and Kent, S. J. (2008), Binding, Internalization, and Antigen Presentation of Vaccine-Loaded Nanoengineered Capsules in Blood. Adv. Mater., 20: 4698–4703. doi: 10.1002/adma.200801826

Author Information

  1. 1

    Centre for Nanoscience and Nanotechnology Department of Chemical and Biomolecular Engineering The University of Melbourne Victoria, 3010 (Australia)

  2. 2

    Department of Microbiology and Immunology The University of Melbourne Victoria 3010 (Australia)

*Centre for Nanoscience and Nanotechnology Department of Chemical and Biomolecular Engineering The University of Melbourne Victoria, 3010 (Australia).

  1. †

    Robert De Rose and Alexander N. Zelikin contributed equally. Supported by National Health and Medical Research Council grants, Australian Research Council grants under the Federation Fellowships and Discovery Project Schemes, and the University of Melbourne Strategic Research Infrastructure Fund. Supporting Information is available online from Wiley InterScience or from the authors.

Publication History

  1. Issue published online: 16 DEC 2008
  2. Article first published online: 17 OCT 2008
  3. Manuscript Received: 1 JUL 2008

Funded by

  • National Health and Medical Research Council
  • Australian Research Council
  • University of Melbourne Strategic Research Infrastructure Fund

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (563K)

Keywords:

  • capsules;
  • immunity;
  • layer-by-layer;
  • particles;
  • vaccine
Thumbnail image of graphical abstract

Nanoengineered microcapsules (shown in green) can be used to encapsulate vaccine antigens conferring protection of the cargo until the capsules are taken up by specialized antigen presenting cells in human blood such as dendritic cells (cell membrane in red, nucleus in blue). This technique offers potential applications for in vivo vaccine delivery.

Get PDF (563K)