Hydrogels in Regenerative Medicine

Authors

  • Brandon V. Slaughter,

    1. Department of Biomedical Engineering, C0800 The University of Texas at Austin Austin, TX 78712 (USA)
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  • Shahana S. Khurshid,

    1. Department of Biomedical Engineering, C0800 The University of Texas at Austin Austin, TX 78712 (USA)
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  • Omar Z. Fisher,

    1. Department of Biomedical Engineering, C0800 The University of Texas at Austin Austin, TX 78712 (USA)
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  • Ali Khademhosseini,

    1. Center for Biomedical Engineering, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
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  • Nicholas A. Peppas

    Corresponding author
    1. Biomaterials, Drug Delivery, Bionanotechnology, and Molecular Recognition Laboratories Department of Chemical Engineering, C0400 The University of Texas at Austin Austin, TX 78712 (USA)
    2. Department of Pharmaceutics, C0400 The University of Texas at Austin Austin, TX 78712 (USA)
    3. Department of Biomedical Engineering, C0800 The University of Texas at Austin Austin, TX 78712 (USA)
    • Biomaterials, Drug Delivery, Bionanotechnology, and Molecular Recognition Laboratories Department of Chemical Engineering, C0400 The University of Texas at Austin Austin, TX 78712 (USA).
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  • Dedicated to Professor Robert Langer on the occasion of his 60th birthday

Abstract

Hydrogels, due to their unique biocompatibility, flexible methods of synthesis, range of constituents, and desirable physical characteristics, have been the material of choice for many applications in regenerative medicine. They can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures, and serve as adhesives or barriers between tissue and material surfaces. In this work, the properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed. Recent research involving several different hydrogels polymerized from a variety of synthetic and natural monomers using typical and novel synthetic methods are highlighted. Finally, special attention is given to the microfabrication techniques that are currently resulting in important advances in the field.

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