Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications


  • The authors would like to thank the European Framework 6 plan for funding (COOP. CT-2005-018060). Supporting Information is available online from Wiley InterScience or from the author.


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Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.