Communication

Enzyme Directed Templating of Artificial Bone Mineral

  1. Erik D. Spoerke1,3,
  2. Shawn G. Anthony1,
  3. Samuel I. Stupp1,2,*

Article first published online: 14 JAN 2009

DOI: 10.1002/adma.200802242

Issue

Advanced Materials

Advanced Materials

Volume 21, Issue 4, pages 425–430, January 26, 2009

Additional Information

How to Cite

Spoerke, E. D., Anthony, S. G. and Stupp, S. I. (2009), Enzyme Directed Templating of Artificial Bone Mineral. Advanced Materials, 21: 425–430. doi: 10.1002/adma.200802242

Author Information

  1. 1

    Department of Materials Science and Engineering Northwestern University, 2220 N. Campus Dr. Evanston, IL 60208 (USA)

  2. 2

    Institute for BioNanotechnology in Medicine and Department of Chemistry and Department of Medicine Northwestern University 2220 Campus Drive, Evanston, IL 60208 (USA)

  3. 3

    Current address: Electronic and Nanostructured Materials, Sandia National Laboratories, 1515 Eubank SE, Albuquerque, NM 87123 (USA)

*Department of Materials Science and Engineering Northwestern University, 2220 N. Campus Dr. Evanston, IL 60208 (USA).

Publication History

  1. Issue published online: 14 JAN 2009
  2. Article first published online: 14 JAN 2009
  3. Manuscript Revised: 10 NOV 2008
  4. Manuscript Received: 1 AUG 2008

Funded by

  • Department of Energy. Grant Number: DEFG02-00ER45810
  • NIH. Grant Number: 5R01DE015920-04

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Keywords:

  • Biomineralization;
  • Hydroxyapatite nanocrystals;
  • Supramolecular materials;
  • Nanofiber gels;
  • Peptide amphiphiles

Graphical Abstract

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An artificial, in vitro biomineralization process that utilizes a nanofiber gel to as a substrate for biomimetic hydroxyapatite mineralization in three dimensions is presented. The system employs the natural enzyme alkaline phosphatase and a phosphorylated, anionic nanofiber gel matrix to template hydroxyapatite nanocrystals with size, shape, and crystallographic orientation resembling natural bone mineral.

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